The Sequence Analysis and Genomics (SAGE) lab at UMass Amherst aims to build and apply computational methods to understand genetic variation. We have a particular emphasis on antibiotic resistant bacteria, which pose a major and evolving public health threat.

Using machine learning applied to genomic sequences, combined with a deep understanding of molecular biology and bacterial genomics, we aim to build models that can both accurately predict antibiotic resistance from genome sequences, and also provide interpretable outputs about the genetic basis of resistance.